Cleveland Browns vs. Buffalo Bills Odds, Pick, Prediction 11/17/22

Cleveland Browns vs. Buffalo Bills

Can the Cleveland Browns earn a much-needed victory to stay in the playoff hunt when they take on the Buffalo Bills? Find out in our best Browns vs. Bills sports betting pick and odds preview as we take a look at the Week 11 tilt of the NFL scheduled to play on Sunday, November 17. 

Buffalo will be looking to snap a two-game losing streak when they host this contest at HighMark Stadium. Despite the losing streak, Buffalo comes in as the favorite at 8.5 points on PointsBet NY Sportsbook, while the total is set at 43.0 points. The clubs are meeting for the first time since 2019 when Cleveland went to Buffalo and earned a 19-16 victory.

Dolphins Rout Browns

The Cleveland Browns (3-6-0, 4-5-0 ATS) were dominated by the Miami Dolphins on Sunday, falling 39-17. Cleveland scored first in this contest, then watched the Dolphins rattle off 24 unanswered points before Cade York finally hit a 37-yard field goal to break the run. The loss dropped Cleveland to 1-3-0 on the road.

The Ground struggled to try to get their offense going, as quarterback Jacoby Brissett completed 22 of 35 passes for 212 yards. He has yet to hit the 300-yard mark this season, but the 212 yards was a step backward, as the quarterback had thrown for at least 258 in each of the previous three contests. Nick Chubb finished with 63 yards rushing on 11 carries and scored one of the two Cleveland touchdowns. Donovan Peoples-Jones had a big day with five catches for 99 yards. The Cleveland defense gave up 491 yards to Miami, including 195 on the ground.

The Browns have seven players on injured reserve. In addition, also out are DE Chase Winovich (hamstring), TE David Njoku (ankle), T Joe Haeg (concussion), LB Jason Phillips (pectoral), T Chris Hubbard (unspecified illness), WR Michael Woods (hamstring), TE Jesse James (bicep), and QB Deshaun Watson (suspension) 

Bills Drop Heartbreaker in OT to Vikings

The Buffalo Bills (6-3-0, 4-4-1 ATS) held a 17-point lead over Minnesota late in the third quarter, but watched the Vikings storm back to win in overtime, 33-30. Two interceptions by quarterback Josh Allen and two fumbles sealed Buffalo’s fate.

Allen completed 29 of 43 passes for 330 yards and also rushed for 84 yards off six carries. He had a huge day statistically, but the two interceptions proved to be critical. However, it was a nice rebound performance by Alan who threw for 205 yards against the Jets the previous week. Stefon Diggs had 12 catches for 128 yards and Devin Singletary carried the ball 13 times for 47 yards and two touchdowns. The Bills defense recorded four sacks, but also gave up 481 total yards, including 334 through the air.

Buffalo will be without DE Greg Rousseau (ankle), S James Poyer (elbow), WR Jamison Crowder (ankle), CB Christian Benford (hand), WR Marquez Stevenson (foot) and G Ike Boettger (Achilles).



0-4 ATS in their last four games on turf.

15-34-2 ATS against teams with a winning record.

24-50-1 ATS in their last 75 games following a loss.


5-2-1 ATS in their last eight games at home.

10-2-2 ATS in their last 14 games against teams with a losing record.

11-5-1 ATS in their last 17 games in November.

Cleveland Browns vs. Buffalo Bills Pick  

Cleveland simply does not have the offensive firepower to keep up with Buffalo. The team has been held to 20 points or fewer in three of their last four games and has lost two of their last three games by at least 22 points. The only close contest in that stretch was against division rival Baltimore, but the team is just 1-5 outside their division.

Buffalo blew last week’s game, as turnovers were the culprit. However, the Cleveland defense has just three interceptions and five fumble recoveries. So, turnovers should not be an issue in this contest. Look for Allen to have a big day against a suspect Cleveland defense.

Pick: Take the Buffalo Bills at -8.5 (-105)

The Total

If there is one thing Buffalo can do, it is to move the ball, ranked first in total yards per game (424.1) and second in passing yards per contest (294.2). They are second in points per contest (27.8). Cleveland is one of the worst defenses in football, ranked 31st in points allowed per game (26.4). So, Buffalo should not have problems scoring at least 30 in this game.

The question will be if Cleveland can come up with a couple of touchdowns. They are 10th in points per game (24.1), but Buffalo has one of the best defenses in football, second in points allowed per game (16.8). Cleveland has gone over in six of their last nine games. Take the over.

Pick: Go over 43.0 (-105)

Author: Nathan Rogers